Yasko’s Comprehensive Methylation Panel or 23andme

There are always people asking me for advise when it comes to the genetic tests
we have out there. There are two tests  that cover the methylation
pathway. One is Dr. Amy Yasko’s test and the other is 23andme.
 

What does Amy Yasko’s methylation panel test for?

 

23andme does not test for the ones highlighted in red.

MTHFR C677T. MTHFR A1298C, MTHFR P39P

SHMT C1420T

AHCY 01, AHCY 02, AHCY 19

CBS C699T, CBS A360A, CBS N212N

VDR Bsm, VDR Taq, VDR Fok

MAO A R297R

ACAT 1-02

COMT V158M, COMT H62H, COMT -61 P199P

MTRR S257T, MTRR A66G, MTRR H595Y, MTRR K350A, MTRR R415T, MTRR A664A

MTR A2756G

SUOX S370S

NOS 3 D298E

BHMT 01
BHMT 02, BHMT 04, BHMT 08

I don’t know when but Dr. Yasko will be testing for 16 CFTR SNPs.

Download Dr. Amy Yasko’s book to read about these genes in more detail.
http://www.holisticheal.com/autism-pathways-to-recovery-book-and-workbook.html

 

What can we find at 23andme?

 

Dr. Amy Yasko’s panel does not test for the ones highlighted in red.

MTHFR C677T. MTHFR A1298C, MTHFR P39P, MTHFR R594Q, MTHFR rs1021737

SHMT C1420T (has a 9% no call)

AHCY 01, AHCY 02, AHCY 19

CBS C699T, CBS A360A, CBS N212N, CBS I278T

VDR Bsm, VDR Taq

MAO A R297R

ACAT 1-02

COMT V158M, COMT H62H, COMT -61 P199P

MTRR A66G, MTRR H595Y, MTRR K350A, MTRR R415T, MTRR A664A

MTR A2756G

BHMT 02, BHMT 04, BHMT 08

23andme tests for 31 CFTR genes

GSTM1 rs12068997, GSTM1 rs4147565, GSTM1 rs4147567, GSTM1 rs4147568, GSTM1 r1056806, GSTM1 rs12562055, GSTM1 rs2239892

APOE rs429358

CTH S4031

GSTP1 A114V, GSTP1 I105V

NAT1 A560G, NAT1 C190T

NAT2 A803G, NAT2 T341C, NAT2 G590A, NAT2 G191A, NAT2 G857A

SOD2 A16V

IL-13 (IgE) C112T

GTSM3 (IgG) GTSM3

3 genes in the HLA region that are linked to Selective IgA deficiency

Factor II

FVL

2 HLA genes related to Mold/ Pollen/ Hay Fever

Over 923,000 SNP’s are tested at 23andme.


Dr. Yasko’s test comes with a comprehensive report.

If you cannot read the data yourself at 23andme you can get someone to help you out. Genetic genie will only test for Dr. Yasko’s SNPs. I have a business where I teach clients how to go into their raw data, read the marker graphs and other charts. I also teach my clients how to incorporate 23andme with snpedia.com.

I will be adding other SNPs in the future.

 
 

Comments ( 17 )

  • a couple of my students have used your service for interpretaion of the 23 and me raw data.

    I would love ot find out more about what you do

    ” I have a business where I teach clients how to go into their raw data, read the marker graphs and other charts. I also teach my clients how to incorporate 23andme with snpedia.com.”

    I am teaching a group of practitoners about testing and interpretation and would like to determine if you are a good resource to share with them.

    thanks

    Dr. Ritamarie Loscalzo

  • Pingback:METHYLATION SNP’s: Testing Options and Information Resources | sherleeholmes

  • Deanna Schmidt

    Good Day,

    I recently got back my results from 23andMe, and need help interpreting the data. Can someone help me?

    Thanks in advance,
    Deanna

    • Istvan

      Hi Deanna!

      To setup a consult for interpretation you may call Sterling from Mondays to Fridays on the following number:
      504-616-0965

  • Jennifer cropper

    IS one of these tests more comprehensive than the other with regard to methylation defects? DO I need to have both to get the full picture. I was planning to get the 23 and me. I am supplementing with methyl folate and most of the other methlylation substrates I was already taking. The folate is definitely helping but something is missing.

    • Istvan

      Well 23andme tests for over 923,000 SNPs but if you are looking at Dr. Yasko’s there are a few critical SNPs there such as SUOX and VDR Fok that 23andme does not cover. I’ve done both tests.

  • I asked 23andme.com about their MTHFR testing, and they actually told me they test for MTHFR 677 only and do not test for MTHFR 1298.
    Genocept also tests for 677 but not 1298, although they may change this in the future.

    • Istvan

      If you go into the browse raw data section of 23andme once you do your test there are 59 MTHFR SNPs that 23andme tests for. Of the 59 SNPs, my program pulls out 13 of them that have peer reviewed research attached. If you would like to see an example of this, I could email you my variant report. My email is beclotaware@gmail.com.

      Sterling

  • Pingback:Our 23andme Results | Operation: Miracle

  • I need help with my raw data on 23/me. Can you help ?
    Thanks , MJ MY EMAIL IS MONICAAJ3059 @ gmail.com.

    • You may call me at 504-616-0965.

      Sterling

  • Anabel

    I need help with my son’s 23nme results. He is autistic and I would like to know of supplementation that can help with mutations

    • We have a list of practitioners at mthfrsupport.com under find a practitioner that can help you. Remember Anabel, the variant report is a blueprint to what can be going on. Just because you have a SNP does not mean it is expressing. If everything on your variant report was expressing, you would be dead. That is why it is important to speak to someone that understands this. For instance if you have MTHFR, you could test for folic (if eating foods with folic and you have MTHFR, and it is truly expressing, folic will be high), folate (if MTHFR is expressing and the gut is diseased and adequate levels of folate are being consumed and folate is low, MTHFR could be expressing), T cells (if folate is low then T Cells are low because folate controls T Cell regulation) and cholesterol (many people who deplete their folate will then deplete their choline and end up with low cholesterol.). So it is important to go to a practitioner that knows what they are doing.

      Sterling

  • Syeda

    Dear Sterling

    I was wondering which one should I go for (23andme or Yasko’s comprehensive?). My kiddo has Autism and G6PD enzyme deficiency.

    Thanks

    • Istvan

      Definetly 23andMe. It offers multiple G6PD SNPs and is always open for research. Practitioners mainly use 23andMe because of the huge database and significane of the SNPs. For example Dr. Amy Yasko’s test does not include the ApoE genotype that is associated with Alzheimer’s disease and CVD. Knowing one’s genotype the necessary dietarey changes could take place to lower cholesterol levels. This is just one gene. Our report features 250+ SNPs and most of Dr. Yasko’s are covered as well.

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