Many antacids contain aluminum. With the MTHFR gene mutation we have trouble clearing metals so aluminum is not a good thing to put in our bodies.
We also have trouble maintaining adequate levels of B12 (methylcobalamin not to be mistaken with cyanocobalamin). Aluminum can inhibit the absorption of B12.
Protein Pump Inhibitors decrease B12 and Folate (not to be mistaken with folic).
Histamine Blockers reduce the absorption of Folate and B12.
Reduces the absorption of B12.
Oral diabetic medications
Causes malabsorption of B12, Folate and possibly B1 (thiamine)
Inhibits B6 (P5P)
Inhibits the absorption of Folate and inactivates B6.
Reduces the absorption of Folate and B12 (methylcobalamin)
Cephalosporins, Fluorquinolones, Isoniazid, Macrolides, Penicillan, Sulfonamides and Tetracyclines
Destroy intestinal gut flora
B1, B2, B5, B6, Folate and B12 all have decreased absorption.
People with MTHFR sometimes have problems clearing sulfates. Molybdenum seems to help people with MTHFR clear sulfates and sulfites as well.
Synthetic B vitamins
Many people I speak with who have MTHFR have problems with synthetic b vitamins. It actually jams up the active b vitamins from doing their job. I avoid vitamins with synthetic b's and foods fortified with synthetic b vitamins.
Synthetic B6 contains formaldahyde
Synthetic Folate known as Folic contains coal tar residue
Synthetic B12 known as cyanocobalamin contains cyanide phosphate 3'
These are not the active forms and with MTHFR you clearly need the active forms of b vitamins to manipulate this enzyme deficiency
Phenytoin and Fosphenytoin
Decreases the absorption of Folate and B12
Decreases the absorption of B12 and Folate.
Will cause B12 (methylcobalmin) deficiency in people with an MTHFR gene mutation that can possibly be severe. Prior to surgery and/or a dental visit it is important to let your doctor and anesthesiologist know that you cannot have nitrous oxide. Nitrous oxide can poduce hyperhomocystenemia and high homocysteine which in turn can cause a life threatning clotting event.
Here is the deal with pancreatic enzymes. You can have low production of pancretic enzymes due to lack of nutrition and what pancreatic enzymes you have in your system can go into override and be depleted due to lack of nutrition. Pancreatic enzymes are needed for the methylation process. Medications and poor diet contribute to this. MTHFR and b deficiency is a clear marker of hypomethylation.
Interferes with absorption of Folate
Can interfere with the absorption of B12
Interferes with B2-riboflavin
Reduce glutathione levels. Many people with MTHFR already have compromised glutathione levels. Low glutathione levels can cause high homocysteine levels which in turn can lead to a clotting event.
Signs of a Folate and B12 deficiency are sometimes anxiety and depression. If you know that you have an MTHFR gene mutation and suffer with anxiety and depression, shouldn't you try B12 (methylcobalimin) and Folate? Also BH4 is doing wonders for people who have the MTHFR gene mutation, anxiety and depression. TMG also helps with this. No one should ever stop taking their medication without first consulting a physician.
Cyclosporine and the MTHFR gene mutation has been found to elevate cardiovascular risk factors in the C677T gene mutation.
Methotrexate is used to treat psoriasis and rheumatoid arthritis. It is known to cause Folate deficiency.
People with the MTHFR deficiency sometimes have problems clearing metals. There are many toxic preservatives in vaccinations. Thimerasol and aluminum are found in many vaccinations. They can cause serious problems to someone with an MTHFR gene mutation. Thimerasol (mercury) and aluminum are known to deplete b vitamins. A person with MTHFR has trouble clearing metals. Mercury and aluminum absorb what b vitamins are in the body.
Amalgam fillings are made up of the toxic metal mercury. Someone with the MTHFR gene mutation who clearly cannot dump metals can have many problems with amalgam fillings. Anytime you chew food or put hot liquid into your mouth, a toxic mercury gas is let off in your mouth. Guess what is right above your mouth? YOUR BRAIN. Mercury depletes your B vitamins.
Fluoride has been linked to lowering glutathione.
Some people with MTHFR are not able to tolerate SAM-e
Side effects are dizziness, gas and headaches. SAM-e is unstable and can be inactive by the time you take it. TMG and BH4 work well in it's place.
Acetaminophen and glutathione deficiency
Many people with MTHFR have lower than normal glutathione levels.
B12 (methylcobalamin) and NAC (N-acetylcysteine) help to elevate glutathione. NAC does have some side effects. People with leaky gut syndrome, asthma and pulmonary hypertension should not use NAC.
In my opinion acetaminophen should be avoided by people who have low glutathione and the MTHFR gene mutation. There are studies out that show acetaminophen lowers your glutathione by 84%.
Diuretics have been linked to causing Thiamine (B1) deficiency.
Antifungals such as grisefulvin and fluconazole are hard on the liver. Glutathione is needed to clear out toxins and to maintain a healthy liver. With MTHFR and low glutathione it is best to avoid these drugs. Oil of oregano, coconut milk and a low carb diet are healthier alternatives that help keep yeast and candida away.
Mercury tends to suck up our methylcobalamin (B12).
It is best to try other alternatives such as flaxseed oil and nattokinase (should not be taken with coumadin). Remember that many people with an MTHFR gene defect have problems clearing heavy metals and there is only one other heavy metal deadlier than mercury. It is plutonium.
People with MTHFR sometimes need asthma medications. B12 (methylcobalamin) helps improve asthma symptoms. B12 is known as an antisulfite agent. Sulfites can cause asthma in people with MTHFR gene mutations because they have trouble converting sulfites. B6 promotes ATP and helps relax bronchial tissue.
Theophylline, albuterol and prednisone have been found to make us B6 deficient.
Can cause B12 and B6 deficiency which can lead to anemia an fatigue. It can also elevate homocysteine and lead to stroke.
Neuroleptics can cause B12 deficiency and neuroleptic malignant syndrome.
Levodopa is used to treat Parkinson's.
It also decreases levels of B12 (methylcobalamin) and Folate.
This can cause polyneuropathy.
Antihypertension drugs interact with NAC (N-acetylcyteine). NAC helps produce glutathione. So if you are taking an antihypertensive drug, it is best not to put NAC in your MTHFR protocol.
Hydralazine increases the excretion of B6.
Oral contraceptives have been found to drop folate by 40%. A person with the MTHFR gene mutation already has trouble keeping adequate amounts of folate in their body. Low levels of folate can elevate homocysteine and lead to a clotting event.
If anyone knows of any other drugs or medical prosthetics that should be added to the list, let me know.